Setd7
Developmental stage
Expressed during all pre-implementation stages in both male and female embryos.
Domain
The SET domain is necessary but not sufficient for histone methyltransferase activity.
Function
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (By similarity). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:12711597). Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (By similarity). Has also methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed:35210392). Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (By similarity). Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (By similarity). Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (PubMed:35210392).
Sequence Similarities
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
Cellular localization
- Nucleus
- Chromosome
Alternative names
Kiaa1717, Set7, Set9, Setd7, Histone-lysine N-methyltransferase SETD7, Histone H3-K4 methyltransferase SETD7, SET domain-containing protein 7, SET7/9, H3-K4-HMTase SETD7