SF1
Function
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.
Post-translational modifications
Phosphorylation on Ser-20 interferes with U2AF2 binding and spliceosome assembly. Isoform 6 is phosphorylated on Ser-463.
Sequence Similarities
Belongs to the BBP/SF1 family.
Tissue Specificity
Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart.
Cellular localization
- Nucleus
Alternative names
ZFM1, ZNF162, SF1, Splicing factor 1, Mammalian branch point-binding protein, Transcription factor ZFM1, Zinc finger gene in MEN1 locus, Zinc finger protein 162, BBP, mBBP