SFRP2
Domain
The FZ domain is involved in binding with Wnt ligands.
Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.
Sequence Similarities
Belongs to the secreted frizzled-related protein (sFRP) family.
Tissue Specificity
Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.
Cellular localization
- Secreted
Alternative names
FRP2, SARP1, FKSG12, UNQ361/PRO697, SFRP2, Secreted frizzled-related protein 2, FRP-2, sFRP-2, Secreted apoptosis-related protein 1, SARP-1