Sfrp2
Developmental stage
During kidney development, expressed at 10.5 dpc in the mesonephric tubules, and at 12.5 dpc strongly expressed in the comma shaped bodies and surrounding ureter stalk. In 14.5 dpc kidney, expressed in the S-shaped bodies. In the developing nervous system, expressed in the presumptive hindbrain and the ventral part of the neural tube from 8.0 dpc onwards. At 9.5 dpc, expression is additionally detected in the mesonephros and the optic vesicle. 10 dpc expression is found in the second and third branchial cleft, in the eye, the ventral neural tube and specific rhombomeres and prosomers. 10.5 dpc brain shows specific expression in the basal and alar plate. In developing eye, expressed at 9.0 dpc in the optic placode, and at 9.5 dpc in the optic vesicle. By 10.5 dpc, expression found in the lens vesicle and the inner layer of the invaginating optic vesicle. Strong expression at 14.5 dpc in the anterior lens epithelium, decreasing thereafter. Expression also found in the prospective neural retina. In developing limbs, expression found at 11.5 dpc in the shoulder and at the distal end of the cartilaginous condensation. At 12.5 dpc, expressed in the foot and hand paddle extending along the digital rays. Expressed, at 13.5 dpc and 14.5 dpc, in the forelimb and hindlimb where the interphalangeal joints will develop. Also expressed at 14.5 dpc between the sternal bands and where the ribs contact the sternum. In other developing structures, expression found at 11.5 dpc, in the maxillary and mandibular component of the first branchial arch, and later, in the loose mesenchyme surrounding cartilage and epithelia of the skull as well as in the whisker follicles. Expressed in the oral mesenchyme lingual to the developing mandibular tooth buds at 13.5 dpc (PubMed:27713059). Expressed in developing teeth, with the highest levels at 15.5 dpc and 16.5 dpc in the mesenchyme and the dental epithelium of the developing molars. Expressed in development smooth muscle surrounding the esophagus at 11.5 dpc, the dorsal aorta and the ductus arteriosus at 14.5 dpc, and the ureter stalk at 15.5 dpc.
Domain
The FZ domain is involved in binding with Wnt ligands.
Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.
Sequence Similarities
Belongs to the secreted frizzled-related protein (sFRP) family.
Tissue Specificity
Highly expressed in the eye. Weaker expression in heart and lung.
Cellular localization
- Secreted
Alternative names
Sarp1, Sdf5, Sfrp2, Secreted frizzled-related protein 2, sFRP-2, Protein SDF5, Secreted apoptosis-related protein 1, SARP-1