SFRP5

Domain

The FZ domain is involved in binding with Wnt ligands.

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

Sequence similarities

Belongs to the secreted frizzled-related protein (sFRP) family.

Tissue specificity

Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.

Cellular localization

• Secreted

Alternative names

• Secreted frizzled-related protein 5
• sFRP-5
• Frizzled-related protein 1b
• Secreted apoptosis-related protein 3
• FRP-1b
• SARP-3
• SFRP5
• SARP3
• FRP1B

Database links

• entrezGene:6425
• omim:604158
• swissprot:Q5T4F7

Target type

Proteins

Molecular weight

35563Da