SFRP5
Domain
The FZ domain is involved in binding with Wnt ligands.
Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.
Sequence Similarities
Belongs to the secreted frizzled-related protein (sFRP) family.
Tissue Specificity
Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.
Cellular localization
- Secreted
Alternative names
FRP1B, SARP3, SFRP5, Secreted frizzled-related protein 5, sFRP-5, Frizzled-related protein 1b, Secreted apoptosis-related protein 3, FRP-1b, SARP-3