SFTPD
GeneName
SFTPD
Summary
SFTPD, also known as SP D, SPD, or CP4, is a 38kDa surfactant protein primarily expressed in the lungs, particularly in alveolar type II cells. It plays a vital role in the innate immune response and surfactant homeostasis, contributing to lung function and defence against pathogens. SFTPD is secreted into the extracellular space and is involved in various processes, including receptor-mediated endocytosis and the regulation of cytokine production. It has carbohydrate-binding properties and can bind to identical proteins, facilitating its function in macrophage chemotaxis and phagocytosis.
Importance
SFTPD is relevant to: - The innate immune response, particularly in the lungs, where it helps to defend against bacterial infections. - Lung diseases, including pulmonary infections and conditions like surfactant deficiency, due to its role in surfactant homeostasis. - Regulation of immune responses, as it negatively regulates T cell proliferation and interleukin-2 production, impacting overall immune function. - The development of lung alveoli, which is essential for proper respiratory function and gaseous exchange.
Top Products
For researchers investigating SFTPD, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-Surfactant protein D/SP-D antibody (ab203309), which is particularly effective for flow cytometry (FC) and has garnered 5 citations, reflecting its reliability in the field. Additionally, we offer the recombinant antibody, Anti-Surfactant protein D/SP-D antibody [EPR21928-209] (ab220423). This recombinant product is validated for multiple applications, including Western blotting (WB), immunohistochemistry (IHC), and immunoprecipitation (IP), making it a versatile choice for researchers seeking consistent performance across experiments. The Human Surfactant Protein D / SP-D ELISA Kit (ab239431), supported by 2 citations, is an excellent option for researchers looking to accurately measure SP-D levels in their samples.
Abcam Product Citation Summary
The use of the Abcam antibody ab203309 for SFTPD detection in human mesenchymal stem cells highlights its relevance in stem cell research and potential applications in regenerative medicine.
Abcam Product Citation Table
Function
Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
Post-translational modifications
The N-terminus is blocked.
Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.
Sequence Similarities
Belongs to the SFTPD family.
Tissue Specificity
Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes).
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
- Secreted
- Extracellular space
- Surface film
Alternative names
COLEC7, PSPD, SFTP4, SFTPD, Pulmonary surfactant-associated protein D, PSP-D, SP-D, Collectin-7, Lung surfactant protein D