Surfactant protein D/SP-D

Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

The N-terminus is blocked.

Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.

S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.

Belongs to the SFTPD family.

Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes).

• Secreted
• Extracellular space
• Extracellular matrix
• Secreted
• Extracellular space
• Surface film

COLEC7, PSPD, SFTP4, SFTPD, Pulmonary surfactant-associated protein D, PSP-D, SP-D, Collectin-7, Lung surfactant protein D

• entrezGene:6441
• omim:178635
• swissprot:P35247

Proteins

Immunology & Infectious Disease

37728Da