Surfactant protein D/SP-D

Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

S-nitrosylation at Cys-34 and Cys-39 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.

Belongs to the SFTPD family.

• Secreted
• Extracellular space
• Extracellular matrix
• Secreted
• Extracellular space
• Surface film

Sftp4, Sftpd, Pulmonary surfactant-associated protein D, PSP-D, SP-D, Lung surfactant protein D

• entrezGene:20390
• swissprot:P50404

Proteins

Immunology & Infectious Disease

37688Da