SFTPD
Function
Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties (By similarity).
Post-translational modifications
Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.
Sequence Similarities
Belongs to the SFTPD family.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
- Secreted
- Extracellular space
- Surface film
Alternative names
Pulmonary surfactant-associated protein D, PSP-D, SP-D, Lung surfactant protein D, SFTPD