Sfxn1
Developmental stage
Very high levels in the liver during the period of embryonic hepatic hemopoiesis.
Function
Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine.
Sequence Similarities
Belongs to the sideroflexin family.
Tissue Specificity
Widely expressed, with highest expression in kidney and liver.
Cellular localization
- Mitochondrion inner membrane
- Multi-pass membrane protein
Alternative names
Sideroflexin-1, Sfxn1