SGSM2
Domain
The Rab-GAP TBC domain possesses GTPase activator activity.
Function
Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:21808068, PubMed:26620560). Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560).
Sequence Similarities
Belongs to the RUTBC family.
Tissue Specificity
Widely expressed.
Cellular localization
- Cytoplasm
- Melanosome
- Melanosomal localization is mediated by RAB9A.
Alternative names
KIAA0397, RUTBC1, SGSM2, Small G protein signaling modulator 2, RUN and TBC1 domain-containing protein 1