SH3GL1

An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.

Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).

Belongs to the endophilin family.

Detected in brain and testis (at protein level). Ubiquitous.

• Cytoplasm
• Early endosome membrane
• Peripheral membrane protein
• Cell projection
• Podosome
• Associated with postsynaptic endosomes in hippocampal neurons.

Sh3p8, Endophilin-A2, Endophilin-2, SH3 domain protein 2B, SH3 domain-containing GRB2-like protein 1, SH3p8

• swissprot:O35964

Proteins

Neuroscience

41492Da