Sh3gl1
Domain
An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.
Function
Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).
Sequence Similarities
Belongs to the endophilin family.
Tissue Specificity
Detected in brain and testis (at protein level). Ubiquitous.
Cellular localization
- Cytoplasm
- Early endosome membrane
- Peripheral membrane protein
- Cell projection
- Podosome
- Associated with postsynaptic endosomes in hippocampal neurons.
Alternative names
Sh3p8, Endophilin-A2, Endophilin-2, SH3 domain protein 2B, SH3 domain-containing GRB2-like protein 1, SH3p8