SH3GL1

An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.

Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).

In some cases of acute leukemia, a translocation results in the formation of a KMT2A/MLL1-EEN fusion gene.

Belongs to the endophilin family.

Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus.

• Cytoplasm
• Early endosome membrane
• Peripheral membrane protein
• Cell projection
• Podosome
• Associated with postsynaptic endosomes in hippocampal neurons.

CNSA1, SH3D2B, Endophilin-A2, EEN fusion partner of MLL, Endophilin-2, Extra eleven-nineteen leukemia fusion gene protein, SH3 domain protein 2B, SH3 domain-containing GRB2-like protein 1, EEN

• swissprot:Q99961

Proteins

Neuroscience

41490Da