SH3GL1
Domain
An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.
Function
Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).
Involvement in disease
In some cases of acute leukemia, a translocation results in the formation of a KMT2A/MLL1-EEN fusion gene.
Sequence Similarities
Belongs to the endophilin family.
Tissue Specificity
Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus.
Cellular localization
- Cytoplasm
- Early endosome membrane
- Peripheral membrane protein
- Cell projection
- Podosome
- Associated with postsynaptic endosomes in hippocampal neurons.
Alternative names
CNSA1, SH3D2B, Endophilin-A2, EEN fusion partner of MLL, Endophilin-2, Extra eleven-nineteen leukemia fusion gene protein, SH3 domain protein 2B, SH3 domain-containing GRB2-like protein 1, EEN