SH3GL2
Domain
An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface.
Function
Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
Sequence Similarities
Belongs to the endophilin family.
Tissue Specificity
Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.
Cellular localization
- Cytoplasm
- Membrane
- Peripheral membrane protein
- Early endosome
- Presynapse
Alternative names
CNSA2, SH3D2A, SH3GL2, Endophilin-A1, EEN-B1, Endophilin-1, SH3 domain protein 2A, SH3 domain-containing GRB2-like protein 2