SH3RF2
Domain
The RING finger domain is required for ubiquitin ligase activity and autoubiquitination.
Function
Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19389623, PubMed:19945436).
Pathway
Protein modification; protein ubiquitination.
Post-translational modifications
Autoubiquitinated.
Sequence Similarities
Belongs to the SH3RF family.
Tissue Specificity
Heart (at protein level). Up-regulated in colon cancer tissues as compared to normal colon tissues (at protein level). Testis. In the heart, present in the apex, left atrium, right atrium, left ventricle and right ventricle, but not in the aorta.
Cellular localization
- Nucleus
Alternative names
POSH3, POSHER, PPP1R39, RNF158, SH3RF2, E3 ubiquitin-protein ligase SH3RF2, Heart protein phosphatase 1-binding protein, POSH-eliminating RING protein, Protein phosphatase 1 regulatory subunit 39, RING finger protein 158, RING-type E3 ubiquitin transferase SH3RF2, SH3 domain-containing RING finger protein 2, HEPP1