Shank1
Developmental stage
Expression increases from low levels at birth to high levels at 3-4 weeks before dropping slightly in adulthood. Expressed in the cortex and the molecular layer of the cerebellum at postnatal day 7. Isoform 2 expression does not change during development of both cortex and cerebellum. Isoform 4 expression decreases significantly during development of cortex but not cerebellum.
Function
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.
Sequence Similarities
Belongs to the SHANK family.
Tissue Specificity
Expressed only in brain (neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum).
Cellular localization
- Cytoplasm
- Synapse
- Postsynaptic density
- Colocalizes with alpha-latrotoxin receptor 1.
Alternative names
SH3 and multiple ankyrin repeat domains protein 1, Shank1, GKAP/SAPAP-interacting protein, SPANK-1, Somatostatin receptor-interacting protein, Synamon, SSTR-interacting protein, SSTRIP