SHC2
Domain
The PID domain mediates binding to the TrkA receptor.
Function
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).
Post-translational modifications
Phosphorylated on tyrosines by the Trk receptors.
Tissue Specificity
Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.
Alternative names
SCK, SHCB, SHC2, SHC-transforming protein 2, Protein Sck, SHC-transforming protein B, Src homology 2 domain-containing-transforming protein C2, SH2 domain protein C2