SHC4
Function
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
Post-translational modifications
Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-424 is required for the interaction with GRB2.
Tissue Specificity
Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential.
Cellular localization
- Postsynaptic cell membrane
- Colocalized with MUSK at the neuromuscular junction.
Alternative names
SHCD, UNQ6438/PRO21364, SHC4, SHC-transforming protein 4, Rai-like protein, SHC-transforming protein D, Src homology 2 domain-containing-transforming protein C4, RaLP, hShcD, SH2 domain protein C4