SHLD1

Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.

• Chromosome

C20orf196, RINN3, SHLD1, Shieldin complex subunit 1, RINN1-REV7-interacting novel NHEJ regulator 3, Shield complex subunit 1

• entrezGene:149840
• swissprot:Q8IYI0

Proteins

Oncology

22938Da