SHLD2

Function

Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893).

Sequence Similarities

Belongs to the SHLD2 family.

Cellular localization

• Nucleus
• Chromosome
• Localizes to nuclear foci in response to DNA damage.

Alternative names

FAM35A, RINN2, SHLD2, Shieldin complex subunit 2, Protein FAM35A, RINN1-REV7-interacting novel NHEJ regulator 2, Shield complex subunit 2

Database links

swissprot:Q86V20 entrezGene:414241 entrezGene:54537 swissprot:A6NDK8