CTC-534A2.2

Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.

• Chromosome
• Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle.

FLJ26957, RINN1, SHLD3, Shieldin complex subunit 3, REV7-interacting novel NHEJ regulator 1, Shield complex subunit 3

• swissprot:Q6ZNX1

Proteins

Oncology

28842Da