SHPRH
Domain
The RING finger mediates E3 ubiquitin ligase activity.
Function
E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.
Pathway
Protein modification; protein ubiquitination.
Sequence Similarities
Belongs to the SNF2/RAD54 helicase family.
Tissue Specificity
Broadly expressed.
Alternative names
KIAA2023, SHPRH, E3 ubiquitin-protein ligase SHPRH, RING-type E3 ubiquitin transferase SHPRH