SIGIRR

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Belongs to the interleukin-1 receptor family.

Mainly expressed in epithelial tissues such as kidney, lung and gut.

• Membrane
• Single-pass type III membrane protein

UNQ301/PRO342, SIGIRR, Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, Toll/interleukin-1 receptor 8, TIR8

• entrezGene:59307
• omim:605478
• swissprot:Q6IA17

Proteins

Immunology & Infectious Disease

45679Da