Signal peptide, CUB and EGF-like domain-containing protein 1
Function
Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.
Post-translational modifications
N-glycosylated.
Could be proteolytically cleaved to release a smaller active fragment.
Tissue Specificity
Detected in endothelial cells. Highly expressed in platelets. Stored in platelet alpha granules, and transferred to the cell surface upon activation and aggregation. A smaller form, probably produced by limited proteolysis, after being released from the storage granules, is associated with thrombus and localized with the subendothelial matrices in atherosclerotic plaques.
Cellular localization
- Secreted
- Cell membrane
- Peripheral membrane protein
Alternative names
SCUBE1