SIMC1
Function
Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SLF2 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication.
Isoform 1
Inhibits the protease activity of CAPN3.
Isoform 5
Inhibits the protease activity of CAPN3.
Tissue Specificity
Isoform 5
Skeletal muscle.
Cellular localization
- Nucleus
- PML body
- Isoform 5
- Cytoplasm
- Cytoplasm
- Myofibril
- Sarcomere
Alternative names
C5orf25, PLEIAD, SIMC1, SUMO-interacting motif-containing protein 1, Platform element for inhibition of autolytic degradation