SIR2rp1
Function
NAD-dependent protein deacetylase, which is involved in repression of RNA polymerase I-mediated expression immediately adjacent to telomeres. It is however not involved in antigenic variation and subtelomeric variant surface glycoprotein (VSG) gene silencing. Plays a role in DNA damage response. Also has ADP-ribosylation activity in vitro.
Sequence Similarities
Belongs to the sirtuin family. Class I subfamily.
Cellular localization
- Nucleus
- Chromosome
- Telomere
- Co-localizes with telomeres and minichromosomes.
Alternative names
SIR2, Tb927.7.1690, SIR2rp1, NAD-dependent protein deacetylase SIR2rp1, Regulatory protein SIR2 homolog 1, SIR2-related protein 1