SIVA1
Function
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
Post-translational modifications
Phosphorylated by ABL2/ARG in response to oxidative stress.
Tissue Specificity
Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.
Cellular localization
- Cytoplasm
- Nucleus
- In the nucleus, accumulates in dot-like structures.
Alternative names
SIVA, SIVA1, Apoptosis regulatory protein Siva, CD27-binding protein, CD27BP