SKIL
Function
May have regulatory role in cell division or differentiation in response to extracellular signals.
Post-translational modifications
Ubiquitinated by RNF111 and ARK2C, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.
Sequence Similarities
Belongs to the SKI family.
Tissue Specificity
Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle.
Alternative names
SNO, SKIL, Ski-like protein, Ski-related oncogene, Ski-related protein