SLAIN2
Domain
The N-terminus forms a two-stranded coiled coil.
Function
Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase.
Post-translational modifications
Is highly phosphorylated during mitosis, but not during interphase. The highly phosphorylated form does not localize at microtubule plus ends and does not interact with MAPRE1 or CKAP5.
Sequence Similarities
Belongs to the SLAIN motif-containing family.
Tissue Specificity
Widely expressed with highest levels in adult liver, testis and ovary, and lowest levels in adult pancreas and spleen and in fetal brain.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Colocalizes with microtubules. Detected at the plus end of growing microtubules.
Alternative names
KIAA1458, SLAIN2, SLAIN motif-containing protein 2