SLC10A2
Function
Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:7592981, PubMed:9458785, PubMed:9856990). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed:7592981, PubMed:9458785, PubMed:9856990). Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids (Probable). Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321).
Involvement in disease
Bile acid malabsorption, primary, 1
PBAM1
An autosomal recessive intestinal disorder associated with chronic watery diarrhea, excess fecal bile acids, steatorrhea and interruption of the enterohepatic circulation of bile acids.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
Tissue Specificity
Mainly expressed in ileum and kidney, lower expression in cecum.
Cellular localization
- Membrane
- Multi-pass membrane protein
Alternative names
ASBT, ISBT, NTCP2, SLC10A2, Ileal sodium/bile acid cotransporter, Apical sodium-dependent bile acid transporter, Ileal Na(+)/bile acid cotransporter, Ileal sodium-dependent bile acid transporter, Na(+)-dependent ileal bile acid transporter, Solute carrier family 10 member 2, IBAT