Slc10a2
Function
Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:10101301). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed:10101301). Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids. Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity).
Sequence Similarities
Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
Tissue Specificity
Expressed in ileum.
Cellular localization
- Membrane
- Multi-pass membrane protein
Alternative names
Ntcp2, Ileal sodium/bile acid cotransporter, Apical sodium-dependent bile acid transporter, Ileal Na(+)/bile acid cotransporter, Ileal sodium-dependent bile acid transporter, Na(+)-dependent ileal bile acid transporter, Solute carrier family 10 member 2, ASBT, IBAT, ISBT