SLC14A1
Function
Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes (PubMed:10514515, PubMed:7797558, PubMed:7989337, PubMed:8997401). Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity). Facilitates water transport in erythrocytes (By similarity).
Sequence Similarities
Belongs to the urea transporter family.
Tissue Specificity
Detected in erythrocytes (at protein level) (PubMed:23219802). Expressed in spleen erythroblasts and tumoral kidney (PubMed:7989337).
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Basolateral cell membrane
- Multi-pass membrane protein
- Restricted to the basolateral membrane in various portions of the urothelium.
Alternative names
HUT11, JK, RACH1, UT1, UTE, SLC14A1, Urea transporter 1, Solute carrier family 14 member 1