SLC14A2
Function
Isoform 1
Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism.
Isoform 2
Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism.
Sequence Similarities
Belongs to the urea transporter family.
Tissue Specificity
Isoform 1
Epressed in the inner medulla of the kidney (at protein level).
Isoform 2
Expressed in the kidney.
Cellular localization
- Isoform 1
- Apical cell membrane
- Multi-pass membrane protein
- Cell membrane
- Multi-pass membrane protein
Alternative names
HUT2, UT2, SLC14A2, Urea transporter 2, Solute carrier family 14 member 2