SLC15A2
Domain
The extracellular domain (ECD) region specifically binds trypsin.
Function
Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:16434549, PubMed:18367661, PubMed:7756356). Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1 (By similarity). In kidney, involved in the absorption of circulating di- and tripeptides from the glomerular filtrate (PubMed:7756356). Can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs (PubMed:16434549). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Mediates transport of bacterial peptidoglycans across the plasma membrane or, in macrophages, the phagosome membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (PubMed:20406817).
Sequence Similarities
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
Tissue Specificity
Expressed in kidney (PubMed:7756356). Not detected in intestine (PubMed:7756356). Highly expressed in macrophages (PubMed:20406817).
Cellular localization
- Apical cell membrane
- Multi-pass membrane protein
- Cytoplasmic vesicle
- Phagosome membrane
- Multi-pass membrane protein
- Cell membrane
- Multi-pass membrane protein
- Associated with the cell membrane in resting macrophages and enriched in phagocytic cups and phagosomes after particle internalization.
Alternative names
PEPT2, SLC15A2, Solute carrier family 15 member 2, Kidney H(+)/peptide cotransporter, Peptide transporter 2