SLC20A1
Domain
Region A confers human cells susceptibility to infection by Gibbon Ape Leukemia Virus (GaLV) and Feline leukemia virus subgroup B (FeLV-B). Substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents viral infection.
Function
Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692).
(Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).
Sequence Similarities
Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
Tissue Specificity
Ubiquitously expressed.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
GLVR1, PIT1, SLC20A1, Sodium-dependent phosphate transporter 1, Gibbon ape leukemia virus receptor 1, Leukemia virus receptor 1 homolog, Phosphate transporter 1, Solute carrier family 20 member 1, GLVR-1, PiT-1