SLC22A17

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

Expressed in brain.

• Cell membrane
• Multi-pass membrane protein
• Vacuole membrane
• Multi-pass membrane protein
• Upon LCN2-binding, it is internalized.

BOCT, BOIT, SLC22A17, Solute carrier family 22 member 17, 24p3 receptor, Brain-type organic cation transporter, Lipocalin-2 receptor, Neutrophil gelatinase-associated lipocalin receptor, 24p3R, NgalR

• entrezGene:51310
• omim:611461
• swissprot:Q8WUG5

Proteins

Immunology & Infectious Disease

57686Da