SLC23A1
Function
Sodium:ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed:10556483, PubMed:10556521, PubMed:10631088, PubMed:36749388). Has retained some ancestral activity toward nucleobases such as urate, an oxidized purine. Low-affinity high-capacity sodium:urate cotransporter, may regulate serum urate levels by serving as a renal urate re-absorber (PubMed:36749388).
Isoform 2
Inactive transporter.
Post-translational modifications
Phosphorylated.
Sequence Similarities
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
Tissue Specificity
Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
SVCT1, YSPL3, SLC23A1, Solute carrier family 23 member 1, Na(+)/L-ascorbic acid transporter 1, Sodium-dependent vitamin C transporter 1, Yolk sac permease-like molecule 3, hSVCT1