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SLC25A27

Function

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family.

Tissue specificity

Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra.

Cellular localization

  • Mitochondrion inner membrane
  • Multi-pass membrane protein

Alternative names

  • Mitochondrial uncoupling protein 4
  • UCP 4
  • Solute carrier family 25 member 27
  • UNQ772/PRO1566
  • UCP4
  • SLC25A27

Target type

Proteins

Molecular weight

36064Da