SLC26A8
Function
Antiporter that mediates the exchange of sulfate and oxalate against chloride ions across a membrane (PubMed:11278976, PubMed:11834742). Stimulates anion transport activity of CFTR (PubMed:22121115, PubMed:23582645). May cooperate with CFTR in the regulation of chloride and bicarbonate ions fluxes required for activation of the ADCY10/PKA pathway during sperm motility and sperm capacitation (By similarity). May play a role in sperm tail differentiation and motility and hence male fertility (By similarity).
Involvement in disease
Spermatogenic failure 3
SPGF3
A disorder characterized by primary infertility, sperm morphologic abnormalities, and moderate to severe asthenozoospermia, condition in which the percentage of progressively motile sperm is abnormally low.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Tissue Specificity
Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell (PubMed:11834742). Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids (PubMed:11278976, PubMed:11834742).
Cellular localization
- Membrane
- Multi-pass membrane protein
- Located at both the annulus and the equatorial segment of the human sperm head.
Alternative names
TAT1, SLC26A8, Testis anion transporter 1, Anion exchange transporter, Solute carrier family 26 member 8