SLC27A1

Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed:12556534, PubMed:20530735, PubMed:21395585, PubMed:28178239). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity). Probably involved in fatty acid transport across the blood barrier (PubMed:21395585).

Belongs to the ATP-dependent AMP-binding enzyme family.

Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver (PubMed:10873384, PubMed:21395585). Expressed in brain gray matter (PubMed:21395585).

• Cell membrane
• Single-pass membrane protein
• Endomembrane system
• Single-pass membrane protein
• Cytoplasm
• Plasma membrane and intracellular membranes, at least in adipocytes. In adipocytes, but not myocytes, insulin via the mTORC1 signaling pathway induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane, paralleled by increased LCFA uptake. Insulin-dependent translocation from the cytoplasm to the cell membrane is regulated by EPRS1. Predominantly cytoplasmic in myocytes.

ACSVL5, FATP1, SLC27A1, Long-chain fatty acid transport protein 1, Arachidonate--CoA ligase, Fatty acid transport protein 1, Long-chain-fatty-acid--CoA ligase, Solute carrier family 27 member 1, Very long-chain acyl-CoA synthetase, FATP-1

• entrezGene:376497
• omim:600691
• swissprot:Q6PCB7

Proteins

Immunology & Infectious Disease

71108Da