SLC27A5
Function
May mediate the import of long-chain fatty acids (LCFA) by facilitating their transport across cell membranes (PubMed:20448275, PubMed:20530735). Also catalyzes the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (PubMed:10479480). Mainly functions as a bile acyl-CoA synthetase catalyzing the activation of bile acids via ATP-dependent formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed:10749848, PubMed:11980911). Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (PubMed:10749848, PubMed:11980911). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate ((25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate or THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity).
Sequence Similarities
Belongs to the ATP-dependent AMP-binding enzyme family.
Tissue Specificity
Predominantly expressed in liver.
Cellular localization
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
- Microsome
- Cell membrane
- Multi-pass membrane protein
Alternative names
ACSB, ACSVL6, FACVL3, FATP5, SLC27A5, Long-chain fatty acid transport protein 5, FATP-5, Fatty acid transport protein 5, Bile acid-CoA ligase, Bile acyl-CoA synthetase, Cholate--CoA ligase, Long-chain-fatty-acid--CoA ligase, Solute carrier family 27 member 5, Very long-chain acyl-CoA synthetase homolog 2, Very long-chain acyl-CoA synthetase-related protein, BA-CoA ligase, BAL, BACS, VLCS-H2, VLCSH2, VLACS-related, VLACSR