SLC27A6
Function
Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed:12556534). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (By similarity). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation such as the heart (PubMed:12556534).
Sequence Similarities
Belongs to the ATP-dependent AMP-binding enzyme family.
Tissue Specificity
Strongly expressed in heart and localizes to cardiac myocytes (PubMed:12556534). Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus.
Cellular localization
- Cell membrane
- Sarcolemma
- Multi-pass membrane protein
- Cell membrane
- Multi-pass membrane protein
- In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36.
Alternative names
ACSVL2, FACVL2, FATP6, SLC27A6, Long-chain fatty acid transport protein 6, FATP-6, Fatty acid transport protein 6, Arachidonate--CoA ligase, Long-chain-fatty-acid--CoA ligase, Solute carrier family 27 member 6, Very long-chain acyl-CoA synthetase homolog 1, VLCSH1, hVLCS-H1