SLC28A3
Function
Sodium-dependent, pyrimidine- and purine-selective (PubMed:11032837, PubMed:15861042, PubMed:16446384, PubMed:17140564, PubMed:21998139). Involved in the homeostasis of endogenous nucleosides (PubMed:11032837, PubMed:15861042). Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine) (PubMed:11032837). Employs a 2:1 sodium/nucleoside ratio (PubMed:11032837). Transports uridine (PubMed:21795683). Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine (PubMed:11032837, PubMed:17140564).
Sequence Similarities
Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
Tissue Specificity
Expressed in pancreas, bone marrow, trachea, mammary gland, liver, prostate, and regions of intestine, brain, lung, placenta, testis, kidney, and heart.
Cellular localization
- Isoform 1
- Cell membrane
- Multi-pass membrane protein
- Isoform 2
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
Alternative names
CNT3, SLC28A3, Solute carrier family 28 member 3, Concentrative Na(+)-nucleoside cotransporter 3, CNT 3, hCNT3