SLC2A2
Function
Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8027028, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969).
Involvement in disease
Fanconi-Bickel syndrome
FBS
Rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.
Sequence Similarities
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Tissue Specificity
Liver, insulin-producing beta cell, small intestine and kidney.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
GLUT2, SLC2A2, GLUT-2