SLC2A4

The dileucine internalization motif is critical for intracellular sequestration.

Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation (PubMed:26240143, PubMed:26629404). Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells (PubMed:26240143, PubMed:26629404). Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell (PubMed:26240143, PubMed:26629404).

Defects in Slc2a4 may be the cause of certain post-receptor defects in non-insulin-dependent diabetes mellitus (NIDDM).

Sumoylated.

Palmitoylated. Palmitoylation by ZDHHC7 controls the insulin-dependent translocation of GLUT4 to the plasma membrane.

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

Expressed in skeletal and cardiac muscles (PubMed:26240143, PubMed:2654938). Expressed in brown and white adipose tissues (PubMed:26240143, PubMed:2654938).

• Cell membrane
• Multi-pass membrane protein
• Endomembrane system
• Multi-pass membrane protein
• Cytoplasm
• Perinuclear region
• Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (PubMed:26240143, PubMed:26629404, PubMed:27354378). The dileucine internalization motif is critical for intracellular sequestration (PubMed:26240143, PubMed:26629404). Insulin stimulation induces translocation to the cell membrane (PubMed:27739494).

Glut4, Slc2a4, GT2, GLUT-4

• entrezGene:20528
• swissprot:P14142

Proteins

Immunology & Infectious Disease

54755Da