SLC2A8
Function
Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (By similarity). Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1 (PubMed:27922102). Also able to mediate the transport of dehydroascorbate.
Sequence Similarities
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Tissue Specificity
Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cytoplasmic vesicle membrane
- Multi-pass membrane protein
- Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration.
Alternative names
GLUT8, GLUTX1, SLC2A8, Glucose transporter type 8, Glucose transporter type X1, GLUT-8