Slc30a8
Function
Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion.
Sequence Similarities
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
Tissue Specificity
Expressed in endocrine pancreatic islet alpha and beta cells. Not detected in the brain.
Cellular localization
- Cytoplasmic vesicle
- Secretory vesicle membrane
- Multi-pass membrane protein
- Cell membrane
- Multi-pass membrane protein
- Associated with insulin and glucagon secretory granules.
Alternative names
Znt8, Slc30a8, Proton-coupled zinc antiporter SLC30A8, Solute carrier family 30 member 8, Zinc transporter 8, ZnT-8