SLC34A2

Function

May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.

Involvement in disease

Pulmonary alveolar microlithiasis

PULAM

Rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early-onset or rapid progression are rare. A 'sandstorm-appearing' chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long-term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance.

None

The disease is caused by variants affecting the gene represented in this entry.

A chromosomal aberration involving SLC34A2 is found in a glioblastoma multiforme cell line U-118MG. Results in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity.

Sequence similarities

Belongs to the SLC34A transporter family.

Tissue specificity

Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.

Cellular localization

• Membrane
• Multi-pass membrane protein

Alternative names

• Sodium-dependent phosphate transport protein 2B
• Sodium-phosphate transport protein 2B
• Na(+)-dependent phosphate cotransporter 2B
• NaPi3b
• Sodium/phosphate cotransporter 2B
• Solute carrier family 34 member 2
• Na(+)/Pi cotransporter 2B
• NaPi-2b
• SLC34A2

Database links

• entrezGene:10568
• omim:604217
• swissprot:O95436

Target type

Proteins

Molecular weight

75759Da