SLC37A1
Function
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
Sequence Similarities
Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
Tissue Specificity
Expressed in numerous tissues, with highest expression in pancreas, kidney, bone marrow, spleen, liver, small intestine, as well as in fetal brain, liver and spleen.
Cellular localization
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
Alternative names
G3PP, SLC37A1, Glucose-6-phosphate exchanger SLC37A1, Glycerol-3-phosphate permease, Solute carrier family 37 member 1, G-3-P permease