SLC37A2
Function
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
Sequence Similarities
Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
Tissue Specificity
Detected in intestine and pancreas. Lower expression is also detected in liver and kidney.
Cellular localization
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
Alternative names
Glucose-6-phosphate exchanger SLC37A2, Solute carrier family 37 member 2, SLC37A2