SLC38A5
Function
Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:11243884). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-L-glutamine cycle and the NMDA receptors activation (By similarity). In addition, contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells therefore, participates in the retinal glutamate-glutamine cycle (By similarity). The transport activity is pH sensitive and Li(+) tolerant (PubMed:11243884). Moreover functions in both direction and is associated with large uncoupled fluxes of protons (By similarity). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). May have a particular importance for modulation of net hepatic glutamine flux (By similarity).
Sequence Similarities
Belongs to the amino acid/polyamine transporter 2 family.
Tissue Specificity
Predominantly expressed in stomach, brain, liver, lung and intestinal tract.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Localized at astroglial membrane.
Alternative names
JM24, SN2, SNAT5, PP7194, SLC38A5, Sodium-coupled neutral amino acid transporter 5, Solute carrier family 38 member 5, System N transporter 2